Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

APOBEC3B (Q9UH17) - Overview - Molecular Target Synopsis

Protein


APOBEC3B, DNA dC->dU-editing enzyme APOBEC-3B
Enzyme Classification 3.5.4.38
UniProt Q9UH17

Also Known as ABC3B_HUMAN, APOBEC3B

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1.

5SXG
CRYSTAL STRUCTURE OF THE CANCER GENOMIC DNA MUTATOR APOBEC3B
RCSB/PDB
Inspect Structure
See all 3D Structures for APOBEC3B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: APOBEC3B is active in the following subcellular-locations: nucleus.
GO terms: APOBEC3B is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project APOBEC3B has gain in 0 cell-lines, loss in 8 cell-lines and no signal in 959 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_N, MDA_MB_435, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EPLC-272H, HCC1143, A-431

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, IMR-90, HeLa-S3

(see details)

3D Structures


For APOBEC3B there are:
9 structures (13 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


APOBEC3B has been screened with compounds ( bioactivities). (see details)