Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

POLL (Q9UGP5) - Overview - Molecular Target Synopsis

Protein


POLL, DNA polymerase lambda
Enzyme Classification 2.7.7.7
UniProt Q9UGP5

Also Known as DPOLL_HUMAN, POLL

DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). Binds PCNA.

5W4G
13 RESIDUE FRAGMENT OF
DNA POLYMERASE LAMBDA
IN THE STRUCTURE OF
IMPORTIN BINDING TO NLS PEPTIDE OF DNA POLYMERASE LAMBDA
RCSB/PDB
Inspect Structure
See all 3D Structures for POLL

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: POLL is active in the following subcellular-locations: nucleus.
GO terms: POLL is active in the following subcellular-locations: nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project POLL has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_4, CCRF_CEM, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-398, NCI-H1581, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)

3D Structures


For POLL there are:
58 structures (100 chains) solved
42 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


POLL has been screened with 118 compounds (198 bioactivities). (see details)