Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCF2 (Q9UG63) - Overview - Molecular Target Synopsis

Protein


ABCF2, ATP-binding cassette sub-family F member 2
UniProt Q9UG63

Also Known as ABCF2_HUMAN, ABCF2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ABCF2 is active in the following subcellular-locations: membrane, mitochondrial envelope.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCF2 has gain in 4 cell-lines, loss in 5 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, SR, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, Hs 746T, COV362

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to ABCF2 there are:
5 structures (9 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis