Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ABCF2 (Q9UG63) - Overview - Molecular Target Synopsis


ABCF2, ATP-binding cassette sub-family F member 2
UniProt Q9UG63

Also Known as ABCF2_HUMAN, ABCF2

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: ABCF2 is active in the following subcellular-locations: membrane, mitochondrial envelope.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ABCF2 has gain in 4 cell-lines, loss in 5 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, SR, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, Hs 746T, COV362

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures

At greater than 35% identity similarity to ABCF2 there are:
5 structures (9 chains) solved
3 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis