EPHA6 (Q9UF33) - Overview - Molecular Target Synopsis
EPHA6, Ephrin type-A receptor 6
Enzyme Classification 18.104.22.168
Also Known as EPHA6_HUMAN, EPHA6, EHK2, HEK12
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via SAM domain) with ANKS1A (via SAM domain).
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UniProt: EPHA6 is active in the following subcellular-locations: membrane.
GO terms: EPHA6 is active in the following subcellular-locations: integral component of plasma membrane, neuron projection, nucleoplasm, plasma membrane, receptor complex.