STK39 (Q9UEW8) - Overview - Molecular Target Synopsis
STK39, STE20/SPS1-related proline-alanine-rich protein kinase
Enzyme Classification 188.8.131.52
Also Known as STK39_HUMAN, STK39, SPAK
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT. The phosphorylated form forms a complex with WNK2. Interacts with RELT.
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UniProt: STK39 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: STK39 is active in the following subcellular-locations: apical plasma membrane, basolateral plasma membrane, cytoplasm, cytoskeleton, cytosol, extrinsic component of membrane, intracellular membrane-bounded organelle, nucleoplasm.