Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

STK39 (Q9UEW8) - Overview - Molecular Target Synopsis


STK39, STE20/SPS1-related proline-alanine-rich protein kinase
Enzyme Classification
UniProt Q9UEW8

Also Known as STK39_HUMAN, STK39, SPAK

May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT. The phosphorylated form forms a complex with WNK2. Interacts with RELT.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: STK39 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: STK39 is active in the following subcellular-locations: apical plasma membrane, basolateral plasma membrane, cytoplasm, cytoskeleton, cytosol, extrinsic component of membrane, intracellular membrane-bounded organelle, nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project STK39 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HT29, HCT_116, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-PREB-1, ATRFLOX, SUP-B15

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

RNA Interference

STK39 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MFM223, VP229. (see details)

3D Structures

For STK39 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

STK39 has been screened with 89 compounds (95 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)