Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FTSJ1 (Q9UET6) - Overview - Molecular Target Synopsis

Protein


FTSJ1, Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
Enzyme Classification 2.1.1.205
UniProt Q9UET6

Also Known as TRM7_HUMAN, FTSJ1

Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FTSJ1 is active in the following subcellular-locations: cytoplasm.
GO terms: FTSJ1 is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FTSJ1 has gain in 1 cell-lines, loss in 60 cell-lines and no signal in 944 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, SN12C, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LN-229, KYSE-70, SCC-9

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to FTSJ1 there are:
3 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis