Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK17A (Q9UEE5) - Overview - Molecular Target Synopsis

Protein


STK17A, Serine/threonine-protein kinase 17A
Enzyme Classification 2.7.11.1
UniProt Q9UEE5

Also Known as ST17A_HUMAN, STK17A, DRAK1

Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
414ENSG00000164543ENST00000319357ENSP00000319192Q9UEE5-1

Sub-cellular localization


UniProt: STK17A is active in the following subcellular-locations: nucleus.
GO terms: STK17A is active in the following subcellular-locations: nuclear speck, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK17A has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_19, SNB_75, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WM-115, NCI-H596, LN-229

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

RNA Interference


STK17A was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: H1793, AC295. (see details)

3D Structures


At greater than 50% identity similarity to STK17A there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK17A has been screened with 476 compounds (794 bioactivities), 33 compounds have bioactivities that show binding affinity of <= 500nM (44 bioactivities). (see details)