Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

STK17A (Q9UEE5) - Overview - Molecular Target Synopsis


STK17A, Serine/threonine-protein kinase 17A
Enzyme Classification
UniProt Q9UEE5

Also Known as ST17A_HUMAN, STK17A, DRAK1

Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: STK17A is active in the following subcellular-locations: nucleus.
GO terms: STK17A is active in the following subcellular-locations: nuclear speck, nucleus, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project STK17A has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SNB_19, SNB_75, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WM-115, NCI-H596, LN-229

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

RNA Interference

STK17A was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: H1793, AC295. (see details)

3D Structures

At greater than 50% identity similarity to STK17A there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

STK17A has been screened with 476 compounds (794 bioactivities), 33 compounds have bioactivities that show binding affinity of <= 500nM (44 bioactivities). (see details)