Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MTFP1 (Q9UDX5) - Overview - Molecular Target Synopsis

Protein


MTFP1, Mitochondrial fission process protein 1
UniProt Q9UDX5

Also Known as MTFP1_HUMAN, MTFP1, MTP18

Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MTFP1 is active in the following subcellular-locations: mitochondrion inner membrane.
GO terms: MTFP1 is active in the following subcellular-locations: integral component of membrane, mitochondrial inner membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MTFP1 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LS 174T, LN-18, NCI-H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HeLa-S3, SK-N-SH

(see details)