Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LPAR3 (Q9UBY5) - Overview - Molecular Target Synopsis

Protein


LPAR3, Lysophosphatidic acid receptor 3
UniProt Q9UBY5

Also Known as LPAR3_HUMAN, LPAR3, EDG7, LPA3

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
353ENSG00000171517ENST00000440886, ENST00000370611ENSP00000395389, ENSP00000359643Q9UBY5-1

Sub-cellular localization


UniProt: LPAR3 is active in the following subcellular-locations: cell membrane.
GO terms: LPAR3 is active in the following subcellular-locations: axon, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LPAR3 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, SK_MEL_28, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 675.T, NCI-H847, HEY

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, SK-N-SH

(see details)

3D Structures


At greater than 50% identity similarity to LPAR3 there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LPAR3 has been screened with 248 compounds (423 bioactivities), 69 compounds have bioactivities that show binding affinity of <= 500nM (111 bioactivities). (see details)