Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GHRL (Q9UBU3) - Overview - Molecular Target Synopsis

Protein


GHRL, Appetite-regulating hormone
UniProt Q9UBU3

Also Known as GHRL_HUMAN, GHRL, MTLRP

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation., Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GHRL is active in the following subcellular-locations: secreted.
GO terms: GHRL is active in the following subcellular-locations: axon, endoplasmic reticulum lumen, extracellular region, extracellular space, glutamatergic synapse, postsynapse, Schaffer collateral - CA1 synapse, secretory granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GHRL has gain in 4 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, HS578T, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SKM-1, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, SK-N-SH, NHLF

(see details)


Screening and Chemistry


GHRL has been screened with 52 compounds (106 bioactivities), 40 compounds have bioactivities that show binding affinity of <= 500nM (59 bioactivities). (see details)