Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RPS6KB2 (Q9UBS0) - Overview - Molecular Target Synopsis


RPS6KB2, Ribosomal protein S6 kinase beta-2
Enzyme Classification
UniProt Q9UBS0

Also Known as KS6B2_HUMAN, RPS6KB2, STK14B

Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RPS6KB2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: RPS6KB2 is active in the following subcellular-locations: cytoplasm, nucleoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RPS6KB2 has gain in 12 cell-lines, loss in 0 cell-lines and no signal in 990 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, T47D, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, SNU-387, Detroit 562

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HeLa-S3

(see details)

RNA Interference

RPS6KB2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PCI30, MDAMB453. (see details)

3D Structures

At greater than 75% identity similarity to RPS6KB2 there are:
18 structures (20 chains) solved
18 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RPS6KB2 has been screened with 171 compounds (238 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)