TRPC4 (Q9UBN4) - Overview - Molecular Target Synopsis
TRPC4, Short transient receptor potential channel 4
Also Known as TRPC4_HUMAN, TRPC4
Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Isoform alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with (via PDZ-binding domain) with SLC9A3R1/NHERF. Interacts with MX1 and RNF24. Interacts (via CIRB domain) with SESTD1 (via spectrin 1 repeat). Interacts with CDH5 and CTNNB1. Interacts with SPTAN1 (via C-terminal spectrin repeats) and SPTBN5 (via C-terminus). Interacts (via protein 4.1-binding domain) with EPB41L2.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|836||ENSG00000133107||ENST00000447043, ENST00000355779||ENSP00000414316, ENSP00000348025||Q9UBN4-3|
|804||ENSG00000133107||ENST00000379679, ENST00000338947||ENSP00000369001, ENSP00000342580||Q9UBN4-6|
UniProt: TRPC4 is active in the following subcellular-locations: cell membrane, membrane.
GO terms: TRPC4 is active in the following subcellular-locations: basolateral plasma membrane, calcium channel complex, cation channel complex, caveola, cell surface, cortical cytoskeleton, integral component of plasma membrane, plasma membrane.