Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RABL2A (Q9UBK7) - Overview - Molecular Target Synopsis

Protein


RABL2A, Rab-like protein 2A
UniProt Q9UBK7

Also Known as RBL2A_HUMAN, RABL2A

Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail. Interacts with IFT27, IFT81, IFT172, ATP6V1E1, HK1, LDHC, MAPRE1 and HSPA2.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: RABL2A is active in the following subcellular-locations: cell.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RABL2A has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H345, Hs 746T, A-375

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to RABL2A there are:
58 structures (125 chains) solved
54 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RABL2A is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RABL2A has been screened with compounds ( bioactivities). (see details)