Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPARGC1A (Q9UBK2) - Overview - Molecular Target Synopsis

Protein


PPARGC1A, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
UniProt Q9UBK2

Also Known as PRGC1_HUMAN, PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation (By similarity). Interacts with PRDM16, LPIN1 and PML (By similarity). Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (By similarity). Interacts with LRPPRC. Interacts with RNF34 (via RING-type zinc finger).

6IZM
10 RESIDUE FRAGMENT OF
PEPTIDE FROM PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORGAMMA COACTIVATOR 1-ALPHA
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF THE PPARGAMMA-LBD COMPLEXED WITH COMPOUND 1L
RCSB/PDB
Inspect Structure
See all 3D Structures for PPARGC1A

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PPARGC1A is active in the following subcellular-locations: cytoplasm, nucleus, pml body.
GO terms: PPARGC1A is active in the following subcellular-locations: apical dendrite, cytosolic ribosome, interfibrillar mitochondrion, intracellular membrane-bounded organelle, neuronal cell body, nuclear euchromatin, nucleoplasm, nucleus, PML body, subsarcolemmal mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPARGC1A has gain in 3 cell-lines, loss in 3 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, UACC_257, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1395, L-363, RPMI 2650

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For PPARGC1A there are:
19 structures (21 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PPARGC1A has been screened with 1 compounds (1 bioactivities). (see details)