PPARGC1A (Q9UBK2) - Overview - Molecular Target Synopsis
PPARGC1A, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Also Known as PRGC1_HUMAN, PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation (By similarity). Interacts with PRDM16, LPIN1 and PML (By similarity). Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (By similarity). Interacts with LRPPRC. Interacts with RNF34 (via RING-type zinc finger).
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UniProt: PPARGC1A is active in the following subcellular-locations: cytoplasm, nucleus, pml body.
GO terms: PPARGC1A is active in the following subcellular-locations: apical dendrite, cytosolic ribosome, interfibrillar mitochondrion, intracellular membrane-bounded organelle, neuronal cell body, nuclear euchromatin, nucleoplasm, nucleus, PML body, subsarcolemmal mitochondrion.