Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCD2 (Q9UBJ2) - Overview - Molecular Target Synopsis

Protein


ABCD2, ATP-binding cassette sub-family D member 2
UniProt Q9UBJ2

Also Known as ABCD2_HUMAN, ABCD2, ALD1, ALDL1, ALDR, ALDRP

Probable transporter. Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
740ENSG00000173208ENST00000308666ENSP00000310688Q9UBJ2-1

Sub-cellular localization


UniProt: ABCD2 is active in the following subcellular-locations: peroxisome membrane.
GO terms: ABCD2 is active in the following subcellular-locations: cytosol, integral component of membrane, peroxisomal membrane, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCD2 has gain in 6 cell-lines, loss in 5 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LP-1, KMS-28PE, KMS-34

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)