Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RG (Q9SPP9) - Overview - Molecular Target Synopsis

Protein


RG, Raucaffricine-O-beta-D-glucosidase
Enzyme Classification 3.2.1.125
UniProt Q9SPP9

Also Known as RG1_RAUSE, RG, VGT

Glucosidase specifically involved in alkaloid biosynthesis leading to the accumulation of several alkaloids, including ajmaline, an important plant-derived pharmaceutical used in the treatment of heart disorders.

3ZJ6
CRYSTAL OF RAUCAFFRICINE GLUCOSIDASE IN COMPLEX WITH INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for RG

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
540Q9SPP9-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project RG has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RG there are:
8 structures (16 chains) solved
5 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

RG is solved in complex with the approved drug(s):

BGC/DEXTROSE (4ATL_A, 4ATL_B, 4EK7_A, 4EK7_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RG has been screened with compounds ( bioactivities). (see details)