Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAN1 (Q9S7J8) - Overview - Molecular Target Synopsis

Protein


RAN1, Copper-transporting ATPase RAN1
Enzyme Classification 7.2.2.8
UniProt Q9S7J8

Also Known as HMA7_ARATH, RAN1, HMA7

Involved in copper import into the cell. Essential for ethylene signaling, which requires copper. Acts by delivering copper to create functional hormone receptors.

3DXS
CRYSTAL STRUCTURE OF A COPPER BINDING DOMAIN FROM HMA7, A P- TYPE ATPASE
RCSB/PDB
Inspect Structure
See all 3D Structures for RAN1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1001Q9S7J8-1

Sub-cellular localization


UniProt: RAN1 is active in the following subcellular-locations: membrane.
GO terms: RAN1 is active in the following subcellular-locations: endosome, Golgi apparatus, integral component of membrane, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAN1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RAN1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis