Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

mgs (Q9RFR0) - Overview - Molecular Target Synopsis

Protein


mgs, Mannosylglycerate synthase
Enzyme Classification 2.4.1.269
UniProt Q9RFR0

Also Known as MGS_RHOMR, mgs

Involved in the biosynthesis of the stress protectant 2-O-alpha-D-mannosyl glycerate (MG) which is produced in response to growth at supraoptimal temperature and salinity, and protects several enzymes against inactivation by temperature, freeze-drying and osmotic stress. Catalyzes the condensation of alpha-GDP-D-mannose (GDP-Man) with D-glycerate to produce alpha-mannosyl-D-glycerate. It is specific for GDP-Man, but it can also use alpha-GDP-D-glucose (GDP-Glc), beta-GDP-D-fructose, alpha-UDP-D-mannose and alpha-UDP-D-glucose as sugar donors. It is specific for D-glycerate, but it can also use D-lactate and glycolate as sugar acceptors. This reaction occurs with a net retention of anomeric configuration; the newly formed glycosidic linkage has the same alpha configuration as the sugar donor. Homotetramer. Dimer of dimers.

2Y4J
MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH LACTATE
RCSB/PDB
Inspect Structure
See all 3D Structures for mgs

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
397Q9RFR0-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project mgs has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For mgs there are:
5 structures (30 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis