Molecular Target Synopsis
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Mapk8ip1 (Q9R237) - Overview - Molecular Target Synopsis

Protein


Mapk8ip1, C-Jun-amino-terminal kinase-interacting protein 1
UniProt Q9R237

Also Known as JIP1_RAT, Mapk8ip1, Ib1, Jip1, Mapk8ip

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. Forms homo- or heterooligomeric complexes (PubMed:16456539). Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2, MAPK10/JNK3, MAP2K7/MKK7, MAP3K11/MLK3 and DLK1. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Interacts, via the PID domain, with ARHGEF28 (By similarity). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with the cytoplasmic domain of APP (By similarity). Interacts with DCLK2, VRK2 and MAP3K7/TAK1. Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAP2K7/MKK7 and MAPK8/JNK1. Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and MAPK9/JNK2 (By similarity). Interacts with SH3RF2 (PubMed:22128169).

2FPD
SAD STRUCTURE DETERMINATION: CRYSTAL STRUCTURE OF THE INTRINSIC DIMERIZATION SH3 DOMAIN OF THE IB1 SCAFFOLD PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for Mapk8ip1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
715Q9R237-3
708Q9R237-1
699Q9R237-2

Sub-cellular localization


UniProt: Mapk8ip1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum membrane, mitochondrion membrane, nucleus, perinuclear region.
GO terms: Mapk8ip1 is active in the following subcellular-locations: axonal growth cone, cell body, cytoplasm, cytosol, dendritic growth cone, dentate gyrus mossy fiber, endoplasmic reticulum membrane, mitochondrial membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Mapk8ip1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Mapk8ip1 there are:
3 structures (16 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis