Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Tpk1 (Q9R0M5) - Overview - Molecular Target Synopsis

Protein


Tpk1, Thiamin pyrophosphokinase 1
Enzyme Classification 2.7.6.2
UniProt Q9R0M5

Also Known as TPK1_MOUSE, Tpk1

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
243Q9R0M5-1
194Q9R0M5-2
63Q9R0M5-3

Gene Copy Number Variation


In COSMIC - Cell Lines Project Tpk1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Tpk1 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Tpk1 has been screened with compounds ( bioactivities). (see details)