Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Sigmar1 (Q9R0C9) - Overview - Molecular Target Synopsis

Protein


Sigmar1, Sigma non-opioid intracellular receptor 1
UniProt Q9R0C9

Also Known as SGMR1_RAT, Sigmar1, Oprs1

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112. Homotrimer (By similarity). Interacts with KCNA2; cocaine consumption leads to increased interaction (By similarity). Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists (PubMed:11149946). Interacts with KCNA4 (PubMed:11988171). Interacts with RNF112 in an oxidative stress-regulated manner.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
223Q9R0C9-1
106Q9R0C9-2

Sub-cellular localization


UniProt: Sigmar1 is active in the following subcellular-locations: cell junction, cell membrane, cell projection, cytoplasmic vesicle, endoplasmic reticulum membrane, growth cone, lipid droplet, membrane, nucleus envelope, nucleus inner membrane, nucleus outer membrane, postsynaptic cell membrane, postsynaptic density, synapse.
GO terms: Sigmar1 is active in the following subcellular-locations: cell junction, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, growth cone, integral component of membrane, lipid droplet, nuclear inner membrane, nuclear outer membrane, postsynaptic density, postsynaptic membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Sigmar1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


Sigmar1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)


Screening and Chemistry


Sigmar1 has been screened with 1548 compounds (2461 bioactivities), 956 compounds have bioactivities that show binding affinity of <= 500nM (1266 bioactivities). (see details)