Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

VP1 (Q9Q6Q5) - Overview - Molecular Target Synopsis

Protein


VP1, RNA-directed RNA polymerase
Enzyme Classification 2.7.7.48
UniProt Q9Q6Q5

Also Known as RDRP_IBDV, VP1

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities. Interacts with VP3 in the cytoplasm.

2QJ1
CRYSTAL STRUCTURE OF INFECTIOUS BURSAL DISEASE VIRUS VP1 POLYMERASE INCUBATED WITH AN OLIGOPEPTIDE MIMICKING THE VP3 C-TERMINUS
RCSB/PDB
Inspect Structure
See all 3D Structures for VP1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
881Q9Q6Q5-1

Sub-cellular localization


UniProt: VP1 is active in the following subcellular-locations: virion.
GO terms: VP1 is active in the following subcellular-locations: virion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project VP1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For VP1 there are:
5 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis