Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC17A7 (Q9P2U7) - Overview - Molecular Target Synopsis

Protein


SLC17A7, Vesicular glutamate transporter 1
UniProt Q9P2U7

Also Known as VGLU1_HUMAN, SLC17A7, BNPI, VGLUT1

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Interacts with SHANK3.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC17A7 is active in the following subcellular-locations: cell junction, cytoplasmic vesicle, membrane, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome.
GO terms: SLC17A7 is active in the following subcellular-locations: cell junction, cerebellar mossy fiber, clathrin-sculpted glutamate transport vesicle membrane, excitatory synapse, integral component of membrane, integral component of synaptic vesicle membrane, plasma membrane, postsynapse, presynaptic active zone, synaptic vesicle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC17A7 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, SK_MEL_5, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-398, COLO-704, TC-71

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLC17A7 has been screened with compounds ( bioactivities). (see details)