Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK26 (Q9P289) - Overview - Molecular Target Synopsis

Protein


STK26, Serine/threonine-protein kinase 26
Enzyme Classification 2.7.11.1
UniProt Q9P289

Also Known as STK26_HUMAN, STK26, MASK, MST4

Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Homodimer (PubMed:20730082). Interacts with PDCD10 (PubMed:17360971, PubMed:19370760, PubMed:20332113). Interacts with GOLGA2 (PubMed:15037601, PubMed:20332113). Interacts with CTTNBP2NL (PubMed:18782753). Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006). Interacts with PDCD10; this interaction is required for the association of STK26 with RIPOR1 (PubMed:27807006).

5YF4
9 RESIDUE FRAGMENT OF
PEPTIDE FROM SERINE/THREONINE-PROTEIN KINASE 26
IN THE STRUCTURE OF
A KINASE COMPLEX MST4-MOB4
RCSB/PDB
Inspect Structure
See all 3D Structures for STK26

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STK26 is active in the following subcellular-locations: cytoplasm, golgi apparatus.
GO terms: STK26 is active in the following subcellular-locations: apical plasma membrane, cell periphery, cytoplasm, cytosol, extracellular exosome, Golgi apparatus, Golgi membrane, Golgi-associated vesicle, membrane, perinuclear region of cytoplasm, vesicle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK26 has gain in 0 cell-lines, loss in 29 cell-lines and no signal in 976 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GTL-16, OCI-M1, OCI-M2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, MCF-7, NHEK

(see details)

RNA Interference


STK26 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PEO14, BEN. (see details)

3D Structures


For STK26 there are:
8 structures (12 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK26 has been screened with 780 compounds (1370 bioactivities), 11 compounds have bioactivities that show binding affinity of <= 500nM (16 bioactivities). (see details)