Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADA2 (Q9NZK5) - Overview - Molecular Target Synopsis

Protein


ADA2, Adenosine deaminase 2
Enzyme Classification 3.5.4.4
UniProt Q9NZK5

Also Known as ADA2_HUMAN, ADA2, ADGF, CECR1, IDGFL

Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. Homodimer. Interacts with adenosine receptors. Binds heparin.

3LGD
CRYSTAL STRUCTURE OF HUMAN ADENOSINE DEAMINASE GROWTH FACTOR, ADENOSINE DEAMINASE TYPE 2 (ADA2)
RCSB/PDB
Inspect Structure
See all 3D Structures for ADA2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADA2 is active in the following subcellular-locations: secreted.
GO terms: ADA2 is active in the following subcellular-locations: azurophil granule lumen, extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADA2 has gain in 2 cell-lines, loss in 4 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


For ADA2 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis