Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

COQ3 (Q9NZJ6) - Overview - Molecular Target Synopsis

Protein


COQ3, Ubiquinone biosynthesis O-methyltransferase, mitochondrial
Enzyme Classification 2.1.1.64
UniProt Q9NZJ6

Also Known as COQ3_HUMAN, COQ3

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
369ENSG00000132423ENST00000254759ENSP00000254759Q9NZJ6-1

Sub-cellular localization


UniProt: COQ3 is active in the following subcellular-locations: mitochondrion inner membrane.
GO terms: COQ3 is active in the following subcellular-locations: extrinsic component of mitochondrial inner membrane, mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project COQ3 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_3, SK_MEL_5, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: VMRC-LCD, DV-90, KYSE-150

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HeLa-S3, NHEK

(see details)