Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SPG21 (Q9NZD8) - Overview - Molecular Target Synopsis

Protein


SPG21, Maspardin
UniProt Q9NZD8

Also Known as SPG21_HUMAN, SPG21, ACP33

May play a role as a negative regulatory factor in CD4-dependent T-cell activation. Interacts with CD4. Interacts with ALDH16A1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SPG21 is active in the following subcellular-locations: cytoplasm, cytosol, endosome membrane, golgi apparatus, membrane, trans-golgi network membrane.
GO terms: SPG21 is active in the following subcellular-locations: cytosol, endosome membrane, Golgi apparatus, intracellular membrane-bounded organelle, trans-Golgi network transport vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SPG21 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, RPMI_8226, NCI_H226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H322T, H322T, GTL-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, SK-N-SH

(see details)