Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AHSP (Q9NZD4) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed10
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria4


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1Y01_A Alpha-hemoglobin-stabilizing protein Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 73.9 15.1 Yes No
2 empty 2.28 67.6 14.4 No No
3 empty 2.73 74.2 6.9 No No
4 empty 2 69.8 11.4 No No
5 empty 2.29 58.5 12.8 No No
6 empty 2.34 61.8 9.4 No No
7 empty 1.75 68.5 8.3 No No
8 empty 2.76 65.1 6.1 No No
9 empty 2.15 56.5 7.7 No No
10 empty 2.97 66.7 5.9 No No
1XZY_A Alpha-hemoglobin-stabilizing protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 63.2 20.5 No No
2 empty 2.84 65.9 21.3 No No
3 empty 2.51 71.6 14.5 No No
4 empty 2.05 71.8 12.6 No No
5 empty 1.92 62.9 17.8 No No
6 empty 2.05 67.7 11.2 No No
7 empty 2.37 72.3 9.7 No No
8 empty 1.77 57.7 9.2 No No
9 empty 2.59 75.6 9.3 No No
10 empty 2.12 69.3 9.9 No No
3OVU_A Alpha-hemoglobin-stabilizing protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 66.8 16 No No
2 empty 2.08 65.2 12.1 No No
3 empty 2.03 73.8 6.5 No No
4 empty 2.25 65.3 11.4 No No
5 empty 2.62 60.5 13.8 No No
6 empty 2.26 56.5 9.3 No No
7 empty 2.51 62.4 9.9 No No
8 empty 1.86 54.2 11.1 No No
9 empty 2.64 55.8 6.9 No No
10 empty 1.69 75.9 5.9 No No
1W0A_A Alpha-hemoglobin-stabilizing protein Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.69 66 15.3 No No
2 empty 2.09 77.6 15.2 No No
3 empty 2.56 56.7 12 No No
4 empty 2.28 76.3 11.6 No No
5 empty 2.02 67.9 9.5 No No
6 empty 1.18 68.3 7.7 No No
7 empty 2.03 47 8.3 No No
8 empty 1.75 74.3 7.5 No No
9 empty 2.48 62 8.5 No No
10 empty 1.39 99.2 0 Yes No
3IA3_A Alpha-hemoglobin-stabilizing protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 64.8 11.7 No No
2 empty 2.3 65 13.8 No No
3 empty 2.46 77.5 7 No No
4 empty 2.64 73.7 6.7 No No
5 empty 2.15 74.7 9.6 No No
6 empty 2.17 71.8 12 No No
7 empty 2.65 67.7 7 No No
8 empty 2.21 56.2 11.1 No No
9 empty 2.74 58.2 11.8 No No
10 empty 2.07 71.3 5.7 No No
3IA3_C Alpha-hemoglobin-stabilizing protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 68.1 13.5 No No
2 empty 2.5 60.6 15.4 No No
3 empty 2.15 73.7 8.1 No No
4 empty 2.53 73.1 9.9 No No
5 empty 2.68 71.9 8.2 No No
6 empty 2.65 65.1 10.3 No No
7 empty 2.52 52.7 8.7 No No
8 empty 2.21 54.7 9.6 No No
9 empty 1.61 81 7.3 No No
10 empty 1.86 60 7.3 No No
1Z8U_A Alpha-hemoglobin-stabilizing protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 63.6 17.1 No No
2 empty 2.03 74.4 10.7 No No
3 empty 2.6 67.5 10.3 No No
4 empty 2.25 69.2 9.6 No No
5 empty 2.17 74.4 8.3 No No
6 empty 2.55 62.5 6.5 No No
7 empty 2.58 58.8 7.3 No No
8 empty 1.81 57.1 9.1 No No
9 empty 2.01 49.6 7.1 No No
10 empty 2.61 68.2 6.5 No No
1Z8U_C Alpha-hemoglobin-stabilizing protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 61 15.7 No No
2 empty 1.99 73.2 10.7 No No
3 empty 2.43 71.5 13.2 No No
4 empty 2.71 68.8 18.3 No No
5 empty 2.2 65.7 11.5 No No
6 empty 2.52 77.4 6.5 No No
7 empty 1.88 47 10 No No
8 empty 2.33 70.5 7.7 No No
9 empty 2.04 63.6 8.6 No No
10 empty 2.55 67.6 7.3 No No
1W0B_A Alpha-hemoglobin-stabilizing protein Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 76.7 16.9 Yes No
2 empty 2.64 69.7 26.5 No No
3 empty 1.98 63.3 14 No No
4 empty 1.8 57.5 14.3 No No
5 empty 2.83 63.2 12.2 No No
6 empty 2.43 75.1 11.8 No No
7 empty 2.54 59.4 11.5 No No
8 empty 2.38 66.3 7.4 No No
9 empty 3.53 65.8 10 No No
10 empty 2.13 50.3 8.7 No No
1W09_A Alpha-hemoglobin-stabilizing protein Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 73.9 14.1 Yes No
2 empty 2.18 69.1 13.8 No No
3 empty 2.2 62.1 12 No No
4 empty 2.56 68.4 10.5 No No
5 empty 2.33 73 9.7 No No
6 empty 2.37 63.8 10.2 No No
7 empty 2.95 62.8 15.2 No No
8 empty 2.34 47.4 10.1 No No
9 empty 2.34 65.4 8.4 No No
10 empty 2.41 65.2 8.2 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed8
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria4

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1W09_A (108983) Alpha-hemoglobin-stabilizing protein Spectrin repeat-like, Alpha-hemoglobin stabilizing protein AHSP, Alpha-hemoglobin stabilizing protein AHSP Yes No
1W0A_A (108984) Alpha-hemoglobin-stabilizing protein Spectrin repeat-like, Alpha-hemoglobin stabilizing protein AHSP, Alpha-hemoglobin stabilizing protein AHSP No No
1W0B_A (108985) Alpha-hemoglobin-stabilizing protein Spectrin repeat-like, Alpha-hemoglobin stabilizing protein AHSP, Alpha-hemoglobin stabilizing protein AHSP Yes No
1XZY_A (116275) Alpha-hemoglobin-stabilizing protein Spectrin repeat-like, Alpha-hemoglobin stabilizing protein AHSP, Alpha-hemoglobin stabilizing protein AHSP No No
1Y01_A (116276) Alpha-hemoglobin-stabilizing protein Spectrin repeat-like, Alpha-hemoglobin stabilizing protein AHSP, Alpha-hemoglobin stabilizing protein AHSP 2.8Å Yes No
1Z8U_A (124724) Alpha-hemoglobin-stabilizing protein Spectrin repeat-like, Alpha-hemoglobin stabilizing protein AHSP, Alpha-hemoglobin stabilizing protein AHSP 2.4Å No No
1Z8U_C (124726) Alpha-hemoglobin-stabilizing protein Spectrin repeat-like, Alpha-hemoglobin stabilizing protein AHSP, Alpha-hemoglobin stabilizing protein AHSP 2.4Å Yes No
3OVU_A (3650960) Alpha-hemoglobin-stabilizing protein Spectrin repeat-like, Alpha-hemoglobin stabilizing protein AHSP, UNMATCHED 2.83Å No No
Ligand-based Druggability Score: -1.55
Ligand-based Druggability Score Percentile: 63%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


AHSP is involved in 8 interactions in the network.


Druggability
Overall Druggability Percentile: 17.87
Druggability for Cancer Therapeutics: 31.63
Druggability for Other Therapeutics: 32.01
Cancer-Associated
Cancer-associated percentile : 43.45
Network Articulation Point
Is AHSP critical for communication in the network?


Detailed Graph Legend:Help