Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GLTP (Q9NZD2) - Overview - Molecular Target Synopsis

Protein


GLTP, Glycolipid transfer protein
UniProt Q9NZD2

Also Known as GLTP_HUMAN, GLTP

Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides. Monomer.

4GHS
CRYSTAL STRUCTURE OF HUMAN GLTP BOUND WITH 12:0 DISULFATIDE (ORTHOROMBIC FORM; TWO SUBUNITS IN ASYMMETRIC UNIT)
RCSB/PDB
Inspect Structure
See all 3D Structures for GLTP

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GLTP is active in the following subcellular-locations: cytoplasm.
GO terms: GLTP is active in the following subcellular-locations: cytosol, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GLTP has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, NCI_H460, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RT4, Hs 746T, BICR 22

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, HSMM

(see details)

3D Structures


For GLTP there are:
22 structures (29 chains) solved
19 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis