Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTR10 (Q9NZ32) - Overview - Molecular Target Synopsis

Protein


ACTR10, Actin-related protein 10
UniProt Q9NZ32

Also Known as ARP10_HUMAN, ACTR10, ACTR11, ARP11

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACTR10 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTR10 is active in the following subcellular-locations: azurophil granule lumen, cytosol, dynactin complex, extracellular region, ficolin-1-rich granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTR10 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, SNB_75, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H82, Hs 746T, OVCAR-8

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures


At greater than 90% identity similarity to ACTR10 there are:
6 structures (6 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis