Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

NKIRAS1 (Q9NYS0) - Overview - Molecular Target Synopsis


NKIRAS1, NF-kappa-B inhibitor-interacting Ras-like protein 1
UniProt Q9NYS0


Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also interacts with c-Rel (REL).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: NKIRAS1 is active in the following subcellular-locations: cytoplasm.
GO terms: NKIRAS1 is active in the following subcellular-locations: cytoplasm, membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project NKIRAS1 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_2, SK_MEL_28, OVCAR_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: A-375, SK-N-FI, SK-MEL-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, HMEC

(see details)

3D Structures

At greater than 35% identity similarity to NKIRAS1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis