Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NKIRAS1 (Q9NYS0) - Overview - Molecular Target Synopsis

Protein


NKIRAS1, NF-kappa-B inhibitor-interacting Ras-like protein 1
UniProt Q9NYS0

Also Known as KBRS1_HUMAN, NKIRAS1, KBRAS1

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also interacts with c-Rel (REL).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NKIRAS1 is active in the following subcellular-locations: cytoplasm.
GO terms: NKIRAS1 is active in the following subcellular-locations: cytoplasm, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NKIRAS1 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, SK_MEL_28, OVCAR_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: A-375, SK-N-FI, SK-MEL-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to NKIRAS1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis