Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RASL12 (Q9NYN1) - Overview - Molecular Target Synopsis

Protein


RASL12, Ras-like protein family member 12
UniProt Q9NYN1

Also Known as RASLC_HUMAN, RASL12, RIS


3C5C
CRYSTAL STRUCTURE OF HUMAN RAS-LIKE, FAMILY 12 PROTEIN IN COMPLEX WITH GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RASL12

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: RASL12 is active in the following subcellular-locations: membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RASL12 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, MCF7, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVKATE, COV413A, COV318

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, SK-N-SH

(see details)

3D Structures


For RASL12 there are:
1 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RASL12 has been screened with compounds ( bioactivities). (see details)