Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

HOXC10 (Q9NYD6) - Overview - Molecular Target Synopsis


HOXC10, Homeobox protein Hox-C10
UniProt Q9NYD6

Also Known as HXC10_HUMAN, HOXC10, HOX3I

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HOXC10 is active in the following subcellular-locations: nucleus.
GO terms: HOXC10 is active in the following subcellular-locations: nuclear body, nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HOXC10 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: T47D, SW_620, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: AN3 CA, RPMI 2650, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, HeLa-S3, NHEK

(see details)

3D Structures

At greater than 75% identity similarity to HOXC10 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

HOXC10 has been screened with compounds ( bioactivities). (see details)