Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXC10 (Q9NYD6) - Overview - Molecular Target Synopsis

Protein


HOXC10, Homeobox protein Hox-C10
UniProt Q9NYD6

Also Known as HXC10_HUMAN, HOXC10, HOX3I

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
342ENSG00000180818ENST00000303460ENSP00000307321Q9NYD6-1
133ENSG00000180818ENST00000515593ENSP00000421946

Sub-cellular localization


UniProt: HOXC10 is active in the following subcellular-locations: nucleus.
GO terms: HOXC10 is active in the following subcellular-locations: nuclear body, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXC10 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, SW_620, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: AN3 CA, RPMI 2650, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, HeLa-S3, NHEK

(see details)

3D Structures


At greater than 75% identity similarity to HOXC10 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXC10 has been screened with compounds ( bioactivities). (see details)