Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A8 (Q9NY64) - Overview - Molecular Target Synopsis

Protein


SLC2A8, Solute carrier family 2, facilitated glucose transporter member 8
UniProt Q9NY64

Also Known as GTR8_HUMAN, SLC2A8, GLUT8, GLUTX1

Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose. Interacts with AP2B1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC2A8 is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle membrane.
GO terms: SLC2A8 is active in the following subcellular-locations: clathrin-coated vesicle membrane, integral component of plasma membrane, lysosomal membrane, plasma membrane, synaptic vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A8 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, SNB_19, EKVX

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C2BBe1, HuH-7, JHH-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, A549

(see details)