Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

STK32B (Q9NY57) - Overview - Molecular Target Synopsis


STK32B, Serine/threonine-protein kinase 32B
Enzyme Classification
UniProt Q9NY57

Also Known as ST32B_HUMAN, STK32B, YANK2

Isoforms / Transcripts (Protein Coding)

Gene Copy Number Variation

In COSMIC - Cell Lines Project STK32B has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: ACHN, MDA_MB_435, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-1, LN-229, WM-115

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, NHLF

(see details)

RNA Interference

STK32B was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CROE33, HUO3N1. (see details)

3D Structures

At greater than 50% identity similarity to STK32B there are:
1 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

STK32B has been screened with 130 compounds (171 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)