Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK32B (Q9NY57) - Overview - Molecular Target Synopsis

Protein


STK32B, Serine/threonine-protein kinase 32B
Enzyme Classification 2.7.11.1
UniProt Q9NY57

Also Known as ST32B_HUMAN, STK32B, YANK2

Isoforms / Transcripts (Protein Coding)


Gene Copy Number Variation


In COSMIC - Cell Lines Project STK32B has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, MDA_MB_435, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-1, LN-229, WM-115

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, NHLF

(see details)

RNA Interference


STK32B was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CROE33, HUO3N1. (see details)

3D Structures


At greater than 50% identity similarity to STK32B there are:
1 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK32B has been screened with 130 compounds (171 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)