Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

KCTD5 (Q9NXV2) - Overview - Molecular Target Synopsis

Protein


KCTD5, BTB/POZ domain-containing protein KCTD5
UniProt Q9NXV2

Also Known as KCTD5_HUMAN, KCTD5

Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (PubMed:18573101). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (PubMed:19361449). Homopentamer (PubMed:19361449). Interacts (via C-terminus) with GRASP55/GORASP2 (PubMed:19361449). Interacts with CUL3 and with ubiquitinated proteins (PubMed:18573101). Interacts with CRY1.

3DRX
X-RAY CRYSTAL STRUCTURE OF HUMAN KCTD5 PROTEIN CRYSTALLIZED IN HIGH- SALT BUFFER
RCSB/PDB
Inspect Structure
See all 3D Structures for KCTD5

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
246ENSG00000167977ENST00000564195ENSP00000456844
234ENSG00000167977ENST00000301738ENSP00000301738Q9NXV2-1

Sub-cellular localization


UniProt: KCTD5 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.
GO terms: KCTD5 is active in the following subcellular-locations: Cul3-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project KCTD5 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, A498, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LCLC-103H, HCC4011, HCC461

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, A549

(see details)

3D Structures


For KCTD5 there are:
3 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis