Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL15 (Q9NXU5) - Overview - Molecular Target Synopsis

Protein


ARL15, ADP-ribosylation factor-like protein 15
UniProt Q9NXU5

Also Known as ARL15_HUMAN, ARL15, ARFRP2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ARL15 is active in the following subcellular-locations: extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL15 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, COLO205, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C2BBe1, OCI-M1, HEL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, NHEK

(see details)

3D Structures


At greater than 35% identity similarity to ARL15 there are:
19 structures (28 chains) solved
19 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL15 has been screened with compounds ( bioactivities). (see details)