Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ARL15 (Q9NXU5) - Overview - Molecular Target Synopsis


ARL15, ADP-ribosylation factor-like protein 15
UniProt Q9NXU5

Also Known as ARL15_HUMAN, ARL15, ARFRP2

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: ARL15 is active in the following subcellular-locations: extracellular exosome.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ARL15 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, COLO205, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C2BBe1, OCI-M1, HEL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, NHEK

(see details)

3D Structures

At greater than 35% identity similarity to ARL15 there are:
19 structures (28 chains) solved
19 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ARL15 has been screened with compounds ( bioactivities). (see details)