Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PAQR5 (Q9NXK6) - Overview - Molecular Target Synopsis

Protein


PAQR5, Membrane progestin receptor gamma
UniProt Q9NXK6

Also Known as PAQR5_HUMAN, PAQR5, MPRG

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PAQR5 is active in the following subcellular-locations: cell membrane.
GO terms: PAQR5 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PAQR5 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A549, EKVX, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SUM 1315M02, HCC515, WiDr

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HeLa-S3, HMEC

(see details)