Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TRMT1 (Q9NXH9) - Overview - Molecular Target Synopsis


TRMT1, tRNA (guanine(26)-N(2))-dimethyltransferase
Enzyme Classification
UniProt Q9NXH9

Also Known as TRM1_HUMAN, TRMT1

Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: TRMT1 is active in the following subcellular-locations: nucleoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TRMT1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, HL_60, PC_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HGC-27, NCI-H1975, SK23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)