Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB20 (Q9NX57) - Overview - Molecular Target Synopsis


RAB20, Ras-related protein Rab-20
UniProt Q9NX57

Also Known as RAB20_HUMAN, RAB20

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: RAB20 is active in the following subcellular-locations: cytoplasmic vesicle, golgi apparatus, phagosome, phagosome membrane.
GO terms: RAB20 is active in the following subcellular-locations: early endosome, endocytic vesicle, endosome, Golgi apparatus, intracellular membrane-bounded organelle, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB20 has gain in 5 cell-lines, loss in 6 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HT29, SW_620, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LS1034, COLO 206F, SW 1463

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, HMEC, CD14-positive monocyte

(see details)

3D Structures

At greater than 35% identity similarity to RAB20 there are:
64 structures (125 chains) solved
57 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis