Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB20 (Q9NX57) - Overview - Molecular Target Synopsis

Protein


RAB20, Ras-related protein Rab-20
UniProt Q9NX57

Also Known as RAB20_HUMAN, RAB20

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
234ENSG00000139832ENST00000267328ENSP00000267328Q9NX57-1

Sub-cellular localization


UniProt: RAB20 is active in the following subcellular-locations: cytoplasmic vesicle, golgi apparatus, phagosome, phagosome membrane.
GO terms: RAB20 is active in the following subcellular-locations: early endosome, endocytic vesicle, endosome, Golgi apparatus, intracellular membrane-bounded organelle, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB20 has gain in 5 cell-lines, loss in 6 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, SW_620, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LS1034, COLO 206F, SW 1463

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, HMEC, CD14-positive monocyte

(see details)

3D Structures


At greater than 35% identity similarity to RAB20 there are:
64 structures (125 chains) solved
57 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis