Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RLIM (Q9NVW2) - Overview - Molecular Target Synopsis

Protein


RLIM, E3 ubiquitin-protein ligase RLIM
Enzyme Classification 2.3.2.27
UniProt Q9NVW2

Also Known as RNF12_HUMAN, RLIM, RNF12

E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. Interacts with LIM/homeobox factors such as LHX3. Interacts with LDB1, LDB2 and SIN3A (By similarity). Interacts with LIMK1 (By similarity). Interacts (via N-terminus) with TERF1. Interacts (via C-terminus) with ESR1.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
624ENSG00000131263ENST00000349225, ENST00000332687ENSP00000253571, ENSP00000328059Q9NVW2-1
483Q9NVW2-2

Sub-cellular localization


UniProt: RLIM is active in the following subcellular-locations: nucleus.
GO terms: RLIM is active in the following subcellular-locations: cytosol, nucleoplasm, nucleus, transcriptional repressor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RLIM has gain in 0 cell-lines, loss in 24 cell-lines and no signal in 981 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, PC_3, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, NCI-H1155, NCI-H1882

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HeLa-S3

(see details)

3D Structures


At greater than 35% identity similarity to RLIM there are:
4 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis