RLIM (Q9NVW2) - Overview - Molecular Target Synopsis
RLIM, E3 ubiquitin-protein ligase RLIM
Enzyme Classification 18.104.22.168
Also Known as RNF12_HUMAN, RLIM, RNF12
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. Interacts with LIM/homeobox factors such as LHX3. Interacts with LDB1, LDB2 and SIN3A (By similarity). Interacts with LIMK1 (By similarity). Interacts (via N-terminus) with TERF1. Interacts (via C-terminus) with ESR1.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|624||ENSG00000131263||ENST00000349225, ENST00000332687||ENSP00000253571, ENSP00000328059||Q9NVW2-1|
UniProt: RLIM is active in the following subcellular-locations: nucleus.
GO terms: RLIM is active in the following subcellular-locations: cytosol, nucleoplasm, nucleus, transcriptional repressor complex.