PRMT7 (Q9NVM4) - Overview - Molecular Target Synopsis
PRMT7, Protein arginine N-methyltransferase 7
Enzyme Classification 126.96.36.1991
Also Known as ANM7_HUMAN, PRMT7, KIAA1933
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and SNRPD3.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|642||ENSG00000132600||ENST00000441236, ENST00000449359||ENSP00000409324, ENSP00000414716||Q9NVM4-3|
UniProt: PRMT7 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.
GO terms: PRMT7 is active in the following subcellular-locations: cytosol, fibrillar center, nucleoplasm, nucleus.