Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL8B (Q9NVJ2) - Overview - Molecular Target Synopsis

Protein


ARL8B, ADP-ribosylation factor-like protein 8B
UniProt Q9NVJ2

Also Known as ARL8B_HUMAN, ARL8B, ARL10C, GIE1

Plays a role in lysosome motility (PubMed:16537643, PubMed:25898167). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (PubMed:15331635). Interacts with tubulin (PubMed:15331635, Ref.16). Interacts with BORCS5; recruits ARL8B to lysosomes (PubMed:25898167).

2AL7
STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 10C
RCSB/PDB
Inspect Structure
See all 3D Structures for ARL8B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARL8B is active in the following subcellular-locations: axon, cell junction, cell projection, cytoplasm, cytoskeleton, late endosome membrane, lysosome membrane, spindle, synapse.
GO terms: ARL8B is active in the following subcellular-locations: axon cytoplasm, cytoplasm, extracellular exosome, late endosome membrane, lysosomal membrane, membrane, midbody, spindle midzone, synapse, vacuolar membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL8B has gain in 1 cell-lines, loss in 8 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, SK_MEL_5, NCI_H226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, MDA-MB-436, OCI-M1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, NHEK

(see details)

3D Structures


For ARL8B there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL8B has been screened with compounds ( bioactivities). (see details)