Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCB8 (Q9NUT2) - Overview - Molecular Target Synopsis

Protein


ABCB8, ATP-binding cassette sub-family B member 8, mitochondrial
UniProt Q9NUT2

Also Known as ABCB8_HUMAN, ABCB8, MABC1

Monomer.

5OCH
THE CRYSTAL STRUCTURE OF HUMAN ABCB8 IN AN OUTWARD-FACING STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for ABCB8

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCB8 is active in the following subcellular-locations: mitochondrion inner membrane.
GO terms: ABCB8 is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, integral component of membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCB8 has gain in 4 cell-lines, loss in 5 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, HT29, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, PE01, MDA-MB-134-VI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures


For ABCB8 there are:
1 structures (8 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCB8 has been screened with compounds ( bioactivities). (see details)