Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ABCF3 (Q9NUQ8) - Overview - Molecular Target Synopsis


ABCF3, ATP-binding cassette sub-family F member 3
UniProt Q9NUQ8

Also Known as ABCF3_HUMAN, ABCF3

Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: ABCF3 is active in the following subcellular-locations: membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ABCF3 has gain in 11 cell-lines, loss in 1 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: T47D, SK_MEL_28, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G122, KYSE-70, NCI-H520

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HeLa-S3

(see details)

3D Structures

At greater than 35% identity similarity to ABCF3 there are:
5 structures (9 chains) solved
3 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis