Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCF3 (Q9NUQ8) - Overview - Molecular Target Synopsis

Protein


ABCF3, ATP-binding cassette sub-family F member 3
UniProt Q9NUQ8

Also Known as ABCF3_HUMAN, ABCF3

Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ABCF3 is active in the following subcellular-locations: membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCF3 has gain in 11 cell-lines, loss in 1 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, SK_MEL_28, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G122, KYSE-70, NCI-H520

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HeLa-S3

(see details)

3D Structures


At greater than 35% identity similarity to ABCF3 there are:
5 structures (9 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis