Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LMBRD1 (Q9NUN5) - Overview - Molecular Target Synopsis

Protein


LMBRD1, Probable lysosomal cobalamin transporter
UniProt Q9NUN5

Also Known as LMBD1_HUMAN, LMBRD1, C6orf209, NESI

Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors., (Microbial infection) Isoform 3: May play a role in the assembly of hepatitis delta virus (HDV). (Microbial infection) Isoform 3: Interacts with hepatitis delta virus NES (HDAg-L).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LMBRD1 is active in the following subcellular-locations: lysosome membrane.
GO terms: LMBRD1 is active in the following subcellular-locations: clathrin-coated endocytic vesicle, integral component of membrane, lysosomal membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LMBRD1 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, SK_MEL_5, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, HM7, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, HSMM

(see details)