Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABHD10 (Q9NUJ1) - Overview - Molecular Target Synopsis

Protein


ABHD10, Mycophenolic acid acyl-glucuronide esterase, mitochondrial
Enzyme Classification 3.1.1.93
UniProt Q9NUJ1

Also Known as ABHDA_HUMAN, ABHD10

Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABHD10 is active in the following subcellular-locations: mitochondrion.
GO terms: ABHD10 is active in the following subcellular-locations: cytosol, mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABHD10 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_116, COLO205, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: ATRFLOX, HCT 116, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, IMR-90

(see details)


Screening and Chemistry


ABHD10 has been screened with compounds ( bioactivities). (see details)