Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BMP2K (Q9NSY1) - Overview - Molecular Target Synopsis

Protein


BMP2K, BMP-2-inducible protein kinase
Enzyme Classification 2.7.11.1
UniProt Q9NSY1

Also Known as BMP2K_HUMAN, BMP2K, BIKE

May be involved in osteoblast differentiation.

5IKW
CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH AN INDAZOLE INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for BMP2K

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: BMP2K is active in the following subcellular-locations: nucleus.
GO terms: BMP2K is active in the following subcellular-locations: nuclear speck, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BMP2K has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HL_60, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SUP-B15, K-562, OCI-M2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, GM12878

(see details)

RNA Interference


BMP2K was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PL5, BT549. (see details)

3D Structures


For BMP2K there are:
5 structures (7 chains) solved
5 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

BMP2K is solved in complex with the approved drug(s):

3JW/BARICITINIB (4W9X_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


BMP2K has been screened with 143 compounds (203 bioactivities), 19 compounds have bioactivities that show binding affinity of <= 500nM (32 bioactivities). (see details)