Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

KIF15 (Q9NS87) - Overview - Molecular Target Synopsis

Protein


KIF15, Kinesin-like protein KIF15
UniProt Q9NS87

Also Known as KIF15_HUMAN, KIF15, KLP2, KNSL7

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. Interacts with MKI67 and TPX2.

4BN2
THE CRYSTAL STRUCTURE OF KINESIN-LIKE PROTEIN KIF15
RCSB/PDB
Inspect Structure
See all 3D Structures for KIF15

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: KIF15 is active in the following subcellular-locations: cytoplasm, cytoskeleton, spindle.
GO terms: KIF15 is active in the following subcellular-locations: centrosome, cytosol, kinesin complex, membrane, microtubule, plus-end kinesin complex, spindle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project KIF15 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, MOLT_4, SF_268

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, Jurkat, Clone E6-1, SU-DHL-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, K562, GM12878

(see details)

3D Structures


For KIF15 there are:
1 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


KIF15 has been screened with compounds ( bioactivities). (see details)