Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC7A10 (Q9NS82) - Overview - Molecular Target Synopsis


SLC7A10, Asc-type amino acid transporter 1
UniProt Q9NS82

Also Known as AAA1_HUMAN, SLC7A10, ASC1

Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: SLC7A10 is active in the following subcellular-locations: membrane.
GO terms: SLC7A10 is active in the following subcellular-locations: integral component of plasma membrane, membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC7A10 has gain in 9 cell-lines, loss in 1 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, HL_60, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-7, HCC1534, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 35% identity similarity to SLC7A10 there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A10 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SLC7A10 has been screened with compounds ( bioactivities). (see details)